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Product Description
– RAS GTPase inhibitor 1 (example 51) is a RAS GTPase inhibitor with anti-tumor activity, extracted from patent WO2018212774A1. RAS GTPase inhibitor 1 (example 51) exhibits an EC50 less than 1 μM for at least one nucleotide exchange and an IC50 less than 1 μM in H727 cells[1].
Web ID
– HY-129189
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C27H28ClF4N5O2
References
– [1]WATERSON, Alex G, et al. QUINAZOLINE COMPOUNDS AS MODULATORS OF RAS SIGNALING. Patent. WO2018212774A1.
CAS Number
– 2252242-32-1
Molecular Weight
– 565.99
SMILES
– CC[C@@H](NC1=C2C=CC=C(C3=CCNCC3)C2=NC(NC4=CC=C(F)C(Cl)=C4)=N1)C5CC5.O=C(O)C(F)(F)F
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Ras
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
