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Ranitidine (hydrochloride)
$72 – $96
Products Details
Product Description
– Ranitidine hydrochloride is a potent, selective and orally active histamine H2-receptor antagonist with an IC50 of 3.3 μM that inhibits gastric secretion. Ranitidine hydrochloride is a weak inhibitor of CYP2C19 and CYP2C9[1][2].
Web ID
– HY-B0281A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C13H23ClN4O3S
References
– [1]Herling, A.W., et al., Inhibition of 14C-aminopyrine accumulation in isolated rabbit gastric glands by the H2-receptor antagonist HOE 760 (TZU-0460). Agents Actions, 1987. 20(1-2): p. 35-9.|[2]Leucuta, A., et al., A pharmacokinetic interaction study between omeprazole and the H2-receptor antagonist ranitidine. Drug Metabol Drug Interact, 2004. 20(4): p. 273-81.|[3] Antonio Francesco Ciccaglione, et al. Pylera® plus ranitidine vs Pylera® plus esomeprazole in first-line treatment of Helicobacter pylori infection: Two pilot studies. Helicobacter. 2019 Oct;24(5):e12606.
CAS Number
– 66357-59-3
Molecular Weight
– 350.86
Compound Purity
– 99.88
SMILES
– CN/C(NCCSCC1=CC=C(CN(C)C)O1)=C[N+]([O-])=O.Cl
Clinical Information
– Launched
Research Area
– Infection; Endocrinology; Metabolic Disease; Cancer
Solubility
– DMSO : 50 mg/mL (ultrasonic)|H2O : ≥ 50 mg/mL
Target
– Bacterial;Cytochrome P450;Histamine Receptor
Isoform
– CYP2;H2 Receptor
Pathway
– Anti-infection;GPCR/G Protein;Immunology/Inflammation;Metabolic Enzyme/Protease;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
