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Products Details
Product Description
– Ranitidine is a potent, selective and orally active histamine H2-receptor antagonist with an IC50 of 3.3 μM that inhibits gastric secretion. Ranitidine is a weak inhibitor of CYP2C19 and CYP2C9[1][2].
Web ID
– HY-B0693
Shipping
– Room temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C13H22N4O3S
References
– [1]A W Herling, et al. Inhibition of 14C-aminopyrine accumulation in isolated rabbit gastric glands by the H2-receptor antagonist HOE 760 (TZU-0460). Agents Actions. 1987 Feb;20(1-2):35-9.|[2]A Leucuta, et al. A pharmacokinetic interaction study between omeprazole and the H2-receptor antagonist ranitidine. Drug Metabol Drug Interact. 2004;20(4):273-81.|[3]Antonio Francesco Ciccaglione, et al. Pylera® plus ranitidine vs Pylera® plus esomeprazole in first-line treatment of Helicobacter pylori infection: Two pilot studies. Helicobacter. 2019 Oct;24(5):e12606.
CAS Number
– 66357-35-5
Molecular Weight
– 314.40
SMILES
– O=[N+](/C=C(NC)/NCCSCC1=CC=C(CN(C)C)O1)[O-]
Clinical Information
– Launched
Research Area
– Infection; Endocrinology; Metabolic Disease; Cancer
Solubility
– 10 mM in DMSO
Target
– Bacterial;Cytochrome P450;Histamine Receptor
Isoform
– CYP2;H2 Receptor
Pathway
– Anti-infection;GPCR/G Protein;Immunology/Inflammation;Metabolic Enzyme/Protease;Neuronal Signaling
Product type
– Reference compound
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