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Products Details
Product Description
– Ranimustine (MCNU) is a nitrosourea alkylating agent, can be used for research of chronic myelogenous leukemia and polycythemia vera[1][3][4].
Web ID
– HY-13739
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C10H18ClN3O7
References
– [1]Kameoka Y, et al. Safety and efficacy of high-dose ranimustine (MCNU) containing regimen followed by autologous stem cell transplantation for diffuse large B-cell lymphoma. Int J Hematol. 2018 Nov;108(5):510-515. |[2]Watanabe S, et al. Chemotherapeutic choice of ranimustine or nimustine on the basis of regional polyamine levels in rat brain. Methods Find Exp Clin Pharmacol. 2008 Mar;30(2):115-20. |[3]Kitajima K, et al. [Chemotherapy of chronic myelogenous leukemia–VP(M) regimen initiated during its chronic phase, and evaluation of MCNU in the phase of blastic crisis]. Gan To Kagaku Ryoho. 1989 Nov;16(11):3573-9. Japanese. |[4]Nagai M, et al. [Therapeutic effect of ranimustine (MCNU) on essential thrombocythemia and polycythemia vera]. Gan To Kagaku Ryoho. 1988 Dec;15(12):3267-70. Japanese.
CAS Number
– 58994-96-0
Molecular Weight
– 327.72
SMILES
– O[C@H]1[C@@H](OC)O[C@H](CNC(N(CCCl)N=O)=O)[C@@H](O)[C@@H]1O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– DNA Alkylator/Crosslinker
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
