Ramelteon metabolite M-II-d3

$450$2,400

Products Details

Product Description

– Ramelteon metabolite M-II-d3 is the deuterium labeled Ramelteon metabolite M-II. Ramelteon metabolite M-II is the major metabolite of Ramelteon, with IC50s of 208 pM, 1470 pM for human melatonin receptors (MT1 or MT2). Ramelteon is a selective melatonin agonist[1][2].

Web ID

– HY-103005S

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Molecular Formula

– C16H18D3NO3

References

– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Nishiyama K, et al. Pharmacological characterization of M-II, the major human metabolite of ramelteon. Pharmacology. 2014;93(3-4):197-201.

CAS Number

– 1246812-22-5

Molecular Weight

– 278.36

Compound Purity

– 99.0

SMILES

– [2H]C([2H])([2H])C(O)C(NCC[C@H]1C2=C(CC1)C=CC3=C2CCO3)=O

Clinical Information

– No Development Reported

Research Area

– Neurological Disease; Endocrinology

Solubility

– 10 mM in DMSO

Target

– Drug Metabolite;Melatonin Receptor

Pathway

– GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling

Product type

– Isotope-Labeled Compounds

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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