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Products Details
Product Description
– Ramatroban-d4 is deuterium labeled Ramatroban. Ramatroban is a selective thromboxane A2 (TxA2, IC50=14 nM) antagonist, which also antagonizes CRTH2 (IC50=113 nM) by inhibiting PGD2 binding.
Web ID
– HY-B0745S
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C21H17D4FN2O4S
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Haba R, et al. Central CRTH2, a second prostaglandin D<sub>2</sub> receptor, mediates emotional impairment in the lipopolysaccharide and tumor-induced sickness behavior model. J Neurosci. 2014 Feb 12;34(7):2514-23.|[3]Stearns BA, et al. Novel tricyclic antagonists of the prostaglandin D<sub>2</sub> receptor DP2 with efficacy in a murine modelof allergic rhinitis. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4647-51.|[4]Sugimoto H, et al. An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D<sub>2</sub>-induced eosinophil migration in vitro. J Pharmacol Exp Ther. 2003 Apr;305(1):347-52.
Molecular Weight
– 420.49
SMILES
– O=C(O)CCN1C2=C(C3=C1C=CC=C3)C[C@H](NS(=O)(C4=C([2H])C([2H])=C(F)C([2H])=C4[2H])=O)CC2
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology; Endocrinology; Cancer
Solubility
– 10 mM in DMSO
Target
– Isotope-Labeled Compounds;Prostaglandin Receptor
Isoform
– TXA2/TP
Pathway
– GPCR/G Protein;Others
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
