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Product Description
– Ralimetinib (LY2228820) is a potent and selective, ATP-competitive inhibitor of p38 MAPK α/β, with IC50s of 5.3 and 3.2 nM, respectively. Ralimetinib (LY2228820) selectively inhibits phosphorylation of MK2 (Thr334), with no effect on phosphorylation of p38α MAPK, JNK, ERK1/2, c-Jun, ATF2, or c-Myc[1].
Web ID
– HY-13241A
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C24H29FN6
Citations
– Cell Biol Int. 2019 Jul 19.|Commun Biol. 2022 Dec 20;5(1):1391.|Eur J Immunol. 2020 Sep;50(9):1350-1361.|Glia. 2020 Jan;68(1):27-43. |bioRxiv. 2023 Feb 8.|Cell Death Dis. 2021 Oct 23;12(11):994.|Cell Rep. 2023 Mar 20;42(3):112275.|EBioMedicine. 2015 Nov 19;2(12):1944-56. |Harvard Medical School LINCS LIBRARY|Mol Med Rep 2019 Jul;20(1):735-744.|Nat Commun. 2021 Dec 3;12(1):6941.|Sci Transl Med. 2018 Jul 18;10(450):eaaq1093.
References
– [1]Campbell RM, et al. Characterization of LY2228820 dimesylate, a potent and selective inhibitor of p38 MAPK with antitumor activity. Mol Cancer Ther. 2014 Feb;13(2):364-74.
CAS Number
– 862505-00-8
Molecular Weight
– 420.53
SMILES
– NC1=NC2=CC=C(C3=C(C4=CC=C(F)C=C4)N=C(C(C)(C)C)N3)N=C2N1CC(C)(C)C
Clinical Information
– Phase 2
Research Area
– Cancer; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Autophagy;p38 MAPK
Isoform
– p38α;p38β
Pathway
– Autophagy;MAPK/ERK Pathway
Product type
– Reference compound
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