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Products Details
Product Description
– (Rac)-Lonafarnib (Sch66336 racemate) is the racemate of Lonafarnib. Lonafarnib is a potent and orally active farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras, K-ras and N-ras with IC50 values of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib also has anti-hepatitis delta virus (HDV) activities[1].
Web ID
– HY-15136B
Shipping
– Room temperature
Molecular Formula
– C27H31Br2ClN4O2
References
– [1]Liu M, et al. Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice. Cancer Res. 1998 Nov 1;58(21):4947-56.
CAS Number
– 193275-86-4
Molecular Weight
– 638.82
SMILES
– O=C(N1CCC(CC(N2CCC(C3C4=C(Br)C=C(Cl)C=C4CCC5=CC(Br)=CN=C53)CC2)=O)CC1)N
Clinical Information
– No Development Reported
Research Area
– Cancer; Infection
Solubility
– 10 mM in DMSO
Target
– Farnesyl Transferase
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
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