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(Rac)-CCT 250863
$962
Only 1000 item(s) left in stock.
Products Details
Product Description
– (Rac)-CCT 250863 (compound rac-21) is a selective and reversible NEK 2 inhibitor with an IC50 of 0.073 µM. (Rac)-CCT 250863 shows good effects of inducing cell cycle arrest and also can antiproliferative in cells (Pomalidomide sensitive/resistant). (Rac)-CCT 250863 induces apoptosis when combines with Pomalidomide[1][2].
Web ID
– HY-117884
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C24H25F3N4O2S
References
– [1]Innocenti P, et al. Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: structure-activity relationship, structural biology, and cellular activity. J Med Chem. 2012 Apr 12;55(7):3228-41. |[2]Ahsan A, et al. Methods for treating cancer with combination therapies. WO2021262962A1.
CAS Number
– 1364269-06-6
Molecular Weight
– 490.54
SMILES
– O=C(N)C1=CC=C(C2=CC(C3=CC(CN(C)C)=CS3)=CN=C2N)C=C1OC(C)/C=CC(F)(F)F
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis
Pathway
– Apoptosis
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
