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Products Details
Product Description
– (rac)-AR-13503 ((rac)-AR-13324 M1 metabolite) is the isoform of AR-13503 (HY-12798C). AR-13503 a ROCK/PKC inhibitor, inhibiting angiogenesis and enhancing retinal pigment epithelium (RPE) permeability. AR-13503 also inhibits the formation of aberrant neovascularization (NV) in oxygen-induced retinopathy (OIR) model in mice[1][2].
Web ID
– HY-125639
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C19H19N3O2
References
– [1]Ding J, et al. ROCK/PKC inhibitor AR-13503 inhibits angiogenesis and protects the barrier function of retinal pigment epithelium[J]. Investigative Ophthalmology & Visual Science, 2018, 59(9): 205-205. |[2]Carbajal K, et al. AR-13503 Enhances the efficacy of aflibercept in a mouse model of proliferative diabetic retinopathy[J]. Investigative Ophthalmology & Visual Science, 2018, 59(9): 200-200.
CAS Number
– 1254032-16-0
Molecular Weight
– 321.37
SMILES
– O=C(C(CN)C1=CC=C(CO)C=C1)NC2=CC3=C(C=C2)C=NC=C3
Clinical Information
– Phase 1
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– PKC;ROCK
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton;Epigenetics;Stem Cell/Wnt;TGF-beta/Smad
Product type
– Reference compound
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