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(rac)-AG-205
$439
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Products Details
Product Description
– (rac)-AG-205 is a potent inhibitor of progesterone receptor membrane component 1 (Pgrmc1) that induces genes involved in sterol synthesis, including the INSIG1 protein, which forms a complex with PGRMC1. (rac)-AG-205 prevents neuronal resistance to hypoxic ischaemia by blocking NF-kB signalling and activation of the BDNF/PI3K/AKT pathway[1].
Web ID
– HY-121012
Shipping
– Room temperature
Molecular Formula
– C22H23ClN6OS
References
– [1]Cahill MA. Unde venisti PGRMC? Grand-Scale Biology from Early Eukaryotes and Eumetazoan Animal Origins. Front Biosci (Landmark Ed). 2022 Nov 30;27(11):317
CAS Number
– 442656-02-2
Molecular Weight
– 454.98
SMILES
– CC1=CC2=C(C=C1)N(C3C2CN(CC3)C)C(CSC4=NN=NN4C5=CC=C(C=C5)Cl)=O
Clinical Information
– No Development Reported
Research Area
– Endocrinology
Solubility
– 10 mM in DMSO
Target
– Akt;NF-κB
Pathway
– NF-κB;PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
