Download Files:

R079

SKU HY-163027-Get quote Category Reference compound Tags Inflammation/Immunology; Neurological Disease, Keap1-Nrf2, NF-κB

Products Details

Product Description

– R079 (compound 17) is a selective, orally active Nrf2 activator. R079 increases Nrf2 translocation activity (EC50 = 32.41 μM). R079 can neutralize excess levels of reactive oxygen species through activating Nrf2. R079 has anti-inflammatory properties and can be used in multiple sclerosis research [1].

Web ID

– HY-163027

Shipping

– Room temperature

Applications

– COVID-19-immunoregulation

Molecular Formula

– C11H11N3O3S

References

– [1] Simon J. Shaw, et al. Tuning the Reactivity of Nuclear Factor Erythroid 2 Related Factor 2 (Nrf2) Activators for Optimal in Vivo Efficacy. ACS Medicinal Chemistry Letters . 2023，Article ASAP.

CAS Number

– 2115659-62-4

Molecular Weight

– 265.29

SMILES

– O=S(/C=C/N1C(N(C=N1)C)=O)(C2=CC=CC=C2)=O

Clinical Information

– No Development Reported

Research Area

– Inflammation/Immunology; Neurological Disease

Solubility

– 10 mM in DMSO

Target

– Keap1-Nrf2

Pathway

– NF-κB

Product type

– Reference compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.