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Product Description
– Quinoprazine is a potent inhibitor of Vaccinia virus DNA synthesis with an IC50 value of 10 μM. Quinoprazine has antimalarial activity against Plasmodium berghei and also displays antiprion potency, significantly decreases PrPSc levels[1]-[5].
Web ID
– HY-147371
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C25H26N4
References
– [1]Mikhaĭlitsyn FS, et al. The search for new antiparasitic agents. 10. The synthesis, toxicological and antimalarial properties of nitrogen-containing heterocycles with a 4-(4-alkylpiperazinyl-1) phenylamine substituent (the preparation quinoprazine). Med Parazitol (Mosk). 1992 Jan-Feb;(1):50-3. Russian. |[2]Ricciardi RP, et al. Therapeutic compounds for blocking DNA synthesis of POX viruses: United States, US20100035887[P]. 2010-02-11.|[3]Renslo AR, et al. Preparation of antiprion compounds containing thiazole-amine for treating neurodegenerative diseases: World Intellectual Property Organization, WO2013033037[P]. 2013-03-07. |[4]Silber BM, et al. Antiprion compounds that reduce PrP(Sc) levels in dividing and stationary-phase cells. Bioorg Med Chem. 2013 Dec 15;21(24):7999-8012. |[5]Mikhaĭlitsyn FS, et al. The search for new antiparasitic agents. 8. The synthesis and study of the acute toxicity, anti-alveolar hydatid and antihymenolepiasis activity of 1-alkyl-4[4-(heterylamino)phenyl]piperazines]. Med Parazitol (Mosk). 1991 Sep-Oct;(5):55-7. Russian.
CAS Number
– 115618-99-0
Molecular Weight
– 382.50
SMILES
– CCN(CC1)CCN1C(C=C2)=CC=C2NC3=C4C=C5C=CC=CC5=CC4=NC=C3
Clinical Information
– No Development Reported
Research Area
– Infection; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Parasite
Isoform
– Plasmodium
Pathway
– Anti-infection
Product type
– Reference compound
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