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Product Description
– Quinidine polygalacturonate is an antiarrhythmic agent. Quinidine polygalacturonate is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine polygalacturonate is also a K+ channel blocker with an IC50 of 19.9 μM, and can induce apoptosis. Quinidine polygalacturonate can be used for malaria research[1][2][3][4].
Web ID
– HY-B1751E
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C20H24N2O2.x(C6H10O7)x
References
– [1]Moody DE, et al. Quinidine inhibits in vivo metabolism of amphetamine in rats: impact upon correlation between GC/MS and immunoassay findings in rat urine. J Anal Toxicol. 1990 Sep-Oct;14(5):311-7.|[2]Kehl SJ, et al. Quinidine-induced inhibition of the fast transient outward K+ current in rat melanotrophs. Br J Pharmacol. 1991 Jul;103(3):1807-13.|[3]Roden DM, et al. Class I antiarrhythmic agents: quinidine, procainamide and N-acetylprocainamide, disopyramide. Pharmacol Ther. 1983;23(2):179-91.|[4]Sang-Yun Lee, et al. Hydrocinchonine, cinchonine, and quinidine potentiate paclitaxel-induced cytotoxicity and apoptosis via multidrug resistance reversal in MES-SA/DX5 uterine sarcoma cells. Environ Toxicol. 2011 Aug;26(4):424-31.|[5]Hassan Jamali, et al. Effect of dextromethorphan/quinidine on pentylenetetrazole- induced clonic and tonic seizure thresholds in mice. Neurosci Lett. 2020 Jun 11;729:134988.
CAS Number
– 27555-34-6
Molecular Weight
– N/A
SMILES
– O=C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C(O)=O.O[C@H]([C@]1([H])[N@@]2C[C@H](C=C)[C@@H](CC2)C1)C3=CC=NC4=CC=C(OC)C=C34.[n].[n]
Clinical Information
– Launched
Research Area
– Cancer; Infection; Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Cytochrome P450;Parasite;Potassium Channel
Isoform
– Plasmodium
Pathway
– Anti-infection;Apoptosis;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
