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Quinacrine (dihydrochloride)
$50
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Products Details
Product Description
– Quinacrine (Mepacrine) dihydrochloride is an orally bioavailable antimalarial agent, which possess anticancer effect both in vitro and vivo. Quinacrine dihydrochloride suppresses NF-κB and activate p53 signaling, which results in the induction of the apoptosis[1].
Web ID
– HY-13735A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C23H32Cl3N3O
References
– [1]Xiaoyang Wu, et al. Quinacrine Inhibits Cell Growth and Induces Apoptosis in Human Gastric Cancer Cell Line SGC-7901. Curr Ther Res Clin Exp. 2012 Feb;73(1-2):52-64.|[2]Anna Eriksson, et al. Towards repositioning of quinacrine for treatment of acute myeloid leukemia – Promising synergies and in vivo effects. Leuk Res. 2017 Dec;63:41-46.
CAS Number
– 69-05-6
Molecular Weight
– 472.88
Compound Purity
– 98.31
SMILES
– CC(NC1=C(C=C(OC)C=C2)C2=NC3=CC(Cl)=CC=C31)CCCN(CC)CC.Cl.Cl
Clinical Information
– Phase 2
Research Area
– Cancer; Infection
Solubility
– DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : 13.89 mg/mL (ultrasonic)
Target
– Apoptosis;Autophagy;Mitophagy;Parasite
Isoform
– Plasmodium
Pathway
– Anti-infection;Apoptosis;Autophagy
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
