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QL-X-138
$235 – $860
Products Details
Product Description
– QL-X-138 is a potent and selective BTK/MNK dual kinase inhibitor, exhibits covalent binding to BTK and non-covalent binding to MNK. QL-X-138 shows IC50s of 9.4 nM, 107.4 nM and 26 nM for BTK, MNK1 and MNK2 kinases respectively. QL-X-138 also shows anti-dengue virus 2 activity, with an IC50 of 3.5 μM. QL-X-138 can be used for the research of B-cell malignancies[1][2].
Web ID
– HY-124645
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C25H19N5O2
References
– [1]Wu H, et, al. Discovery of a BTK/MNK dual inhibitor for lymphoma and leukemia. Leukemia. 2016 Jan;30(1):173-81.|[2]Wispelaere M, et, al. Discovery of host-targeted covalent inhibitors of dengue virus. Antiviral Res. 2017 Mar;139:171-179.
CAS Number
– 1469988-63-3
Molecular Weight
– 421.45
SMILES
– C=CC(NC1=CC(N2C(C=CC3=C2C4=CC(C5=CNN=C5)=CC=C4N=C3)=O)=CC=C1C)=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Infection
Solubility
– 10 mM in DMSO
Target
– Btk;Flavivirus;MNK
Pathway
– Anti-infection;MAPK/ERK Pathway;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
