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Pyrotinib
$228 – $3,540
Products Details
Product Description
– Pyrotinib (SHR-1258) is a potent and selective EGFR/HER2 dual inhibitor with IC50s of 13 and 38 nM, respectively[1].
Web ID
– HY-104065
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C32H31ClN6O3
Citations
– Biosci Rep. 2020 Feb 28;40(2):BSR20194167.|Cell Rep Med. 2023 Jan 10;100911.|Int J Biol Macromol. 2023 May 19;242(Pt 2):124870.|J Med Chem. 2019 May 9;62(9):4772-4778.|J Thorac Oncol. 2023 Sep 5;S1556-0864(23)00802-X.|Lung Cancer. 2018 Dec;126:72-79.|Patent. US 20220175778A1.|Patent. US20210361655A1.|Open Life Sci. 2023, 18(1).
References
– [1]Li X, et al. Discovery and development of Pyrotinib: A novel irreversible EGFR/HER2 dual tyrosine kinase inhibitor with favorable safety profiles for the treatment of breast cancer. Eur J Pharm Sci. 2017 Jan 21. pii: S0928-0987(17)30043-X.
CAS Number
– 1269662-73-8
Molecular Weight
– 583.08
Compound Purity
– 99.80
SMILES
– O=C(NC1=C(OCC)C=C2N=CC(C#N)=C(NC3=CC=C(OCC4=NC=CC=C4)C(Cl)=C3)C2=C1)/C=C/[C@@H]5N(C)CCC5
Clinical Information
– Launched
Research Area
– Cancer
Solubility
– DMSO : 10 mg/mL (ultrasonic;adjust pH to 6 with HCl)
Target
– EGFR
Isoform
– EGFR/ErbB1/HER1;ErbB2/HER2
Pathway
– JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
