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Product Description
– Pyridostatin (RR82) is a G-quadruplex DNA stabilizing agent (Kd=490 nM). Pyridostatin promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. Pyridostatin targets the proto-oncogene Src. Pyridostatin reduced SRC protein levels and SRC-dependent cellular motility in human breast cancer cells[1][2].
Web ID
– HY-15176
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C31H32N8O5
Citations
– ACS Omega. 2023 Sep 25.|Biochem Mol Biol Educ. 2020 Jul;48(4):329-336.|Int J Biol Macromol. 28 August 2021.|iScience. 9 October 2022, 105312.|J Med Virol. 2022 Nov 11.|J Natl Cancer Inst. 2023 Jul 22;djad142.|Nucleic Acids Res. 2019 Aug 22;47(14):7306-7320.|Nucleic Acids Res. 2022 Jun 24;50(12):6953-6967.|J Am Chem Soc. 2021 Dec 6.|J Hepatol. 2020 Aug;73(2):371-382.|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.|Nat Commun. 2022 Mar 17;13(1):1444.|Nat Commun. 2022 Sep 16;13(1):5456.|Nucleic Acids Res. 2023 Sep 22;gkad759.|PLoS Pathog. 2023 Jan 26;19(1):e1011131.
References
– [1]Rodriguez R, et al. Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat Chem Biol. 2012;8(3):301-310. Published 2012 Feb 5.|[2]Koirala D, et al. A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands. Nat Chem. 2011;3(10):782-787. Published 2011 Aug 28.|[3]Moruno-Manchon JF, Koellhoffer EC, Gopakumar J, et al. The G-quadruplex DNA stabilizing drug pyridostatin promotes DNA damage and downregulates transcription of Brca1 in neurons. Aging (Albany NY). 2017;9(9):1957-1970.
CAS Number
– 1085412-37-8
Molecular Weight
– 596.64
SMILES
– O=C(C1=CC(OCCN)=CC(C(NC2=NC3=C(C(OCCN)=C2)C=CC=C3)=O)=N1)NC4=CC(OCCN)=C5C=CC=CC5=N4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– G-quadruplex
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
