Download Files:
Products Details
Product Description
– PVD-06 is a selective PTPN2 degrader (PTPN2/PTP1B selectivity index >60-fold) and induces PTPN2 degradation in a ubiquitination- and proteasome-dependent manner. PVD-06 promotes T cell activation and amplifies IFN-γ-mediated cytotoxicity. PVD-06 has anticancer activity[1].
Web ID
– HY-149760
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C48H55F4N9O11S2
References
– [1]Hu L et al. Discovery of PVD-06 as a Subtype-Selective and Efficient PTPN2 Degrader. J Med Chem. 2023 Nov 23;66(22):15269-15287.
Molecular Weight
– 1074.13
SMILES
– OC(C(F)(F)F)=O.O=C(CN1N=CC(C2=CC=C3C=C(C(N4CC(NS4(=O)=O)=O)=C(C3=C2)F)O)=C1)NCCCCCC(N[C@@H](C(C)(C)C)C(N5C[C@H](O)C[C@H]5C(N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C)=O)=O)=O
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– Phosphatase
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
