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Products Details
Product Description
– PV1115 is a potent and highly selective Chk2 inhibitor with an IC50 of 0.14 nM, 66000 nM, >100000 nM for Chk2, Chk1 and RSK2, respectively. PV1115 is situated within the ATP-binding pocket of Chk2[1].
Web ID
– HY-119699
Shipping
– Room temperature
Molecular Formula
– C20H19N7O3
References
– [1]George T Lountos,
et al. Structural characterization of inhibitor complexes with
checkpoint kinase 2 (Chk2), a drug target for cancer therapy. J Struct Biol.
2011 Dec;176(3):292-301.
CAS Number
– 1093793-10-2
Molecular Weight
– 405.41
SMILES
– O=C(NC1=CC=C(C=C1)/C(C)=N/NC2=NCCN2)C3=CC4=C(C([N+]([O-])=O)=CC=C4)N3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Checkpoint Kinase (Chk)
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
