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Product Description
– Purmorphamine (GMP) is Purmorphamine (HY-15108) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Purmorphamine is a smoothened/Smo receptor agonist with an EC50 of 1 μM[1].
Web ID
– HY-15108G
Shipping
– Room temperature
Molecular Formula
– C31H32N6O2
Citations
– Life Sci. 2023 Jul 29;329:121990.|Biochem Biophys Res Commun. 12 August 2021.|Burns Trauma. 2019 Sep 23;7:29.|Cancer Med. 2018 Nov;7(11):5704-5715.|J Exp Clin Cancer Res. 2018 Nov 27;37(1):287. |Med Oncol. 2021 Mar 17;38(4):41.|Mil Med Res. 2020 Nov 1;7(1):52.|Mil Med Res. 2020 Sep 6;7(1):42. |Oncol Lett. 2019 Sep;18(3):3081-3091.|Patent. US20180263995A1.|Pharmacol Res. 2021 Jan 26;105460.
References
– [1]Hua T, et al. Phenotypic, metabolic, and biogenesis properties of human stem cell-derived cerebellar spheroids. Sci Rep. 2022 Jul 27;12(1):12880. |[2]Sharma R, et al. 3D Bioprinting Pluripotent Stem Cell Derived Neural Tissues Using a Novel Fibrin Bioink Containing Drug Releasing Microspheres. Front Bioeng Biotechnol. 2020 Feb 11;8:57. |[3]Sundberg M, et al. Improved cell therapy protocols for Parkinson’s disease based on differentiation efficiency and safety of hESC-, hiPSC-, and non-human primate iPSC-derived dopaminergic neurons. Stem Cells. 2013 Aug;31(8):1548-62. |[4]Karumbayaram S, et al. Directed differentiation of human-induced pluripotent stem cells generates active motor neurons. Stem Cells. 2009 Apr;27(4):806-11. |[5]Hu Y, et al. Directed differentiation of basal forebrain cholinergic neurons from human pluripotent stem cells. J Neurosci Methods. 2016 Jun 15;266:42-9.
CAS Number
– 483367-10-8
Molecular Weight
– 520.62
SMILES
– N1(C2=CC=C(NC3=NC(OC4=CC=CC5=C4C=CC=C5)=NC6=C3N=CN6C7CCCCC7)C=C2)CCOCC1
Clinical Information
– No Development Reported
Research Area
– Neurological Disease; Cancer
Solubility
– 10 mM in DMSO
Target
– Smo
Pathway
– Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
