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Products Details
Product Description
– Purine phosphoribosyltransferase-IN-1 (Compound (S,R)-48) is a potent inhibitor of the Plasmodium falciparum (Pf), P. vivax (Pv) and Trypanosoma brucei (Tbr) 6-oxopurine purine phosphoribosyltransferases (PRTs), with Ki values of 50, 20, and 2 nM, respectively[1].
Web ID
– HY-144294
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C11H15N5Na4O10P2
References
– [1]Tomáš Klejch, et al. Stereo-Defined Acyclic Nucleoside Phosphonates are Selective and Potent Inhibitors of Parasite 6-Oxopurine Phosphoribosyltransferases. J Med Chem. 2022 Mar 10;65(5):4030-4057.
CAS Number
– 2784631-28-1
Molecular Weight
– 531.17
SMILES
– O=P(O[Na])(O[Na])COC[C@@H](OC[C@@H](P(O[Na])(O[Na])=O)O)CN1C=NC2=C1N=C(N)NC2=O
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Parasite
Isoform
– Plasmodium
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
