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Purfalcamine
$500 – $4,600
Products Details
Product Description
– Purfalcamine is an orally active, selective Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) inhibitor with an IC50 of 17 nM and an EC50 of 230 nM. Purfalcamine has antimalarial activity and causes malaria parasites developmental arrest at the schizont stage[1][2].
Web ID
– HY-117015
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C29H33FN8O
References
– [1]Nobutaka Kato, et al. Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility. Nat Chem Biol. 2008 Jun;4(6):347-56.|[2]Rajshekhar Y Gaji, et al. Expression of the essential Kinase PfCDPK1 from <i>Plasmodium falciparum</i> in <i>Toxoplasma gondii</i> facilitates the discovery of novel antimalarial drugs. Antimicrob Agents Chemother. 2014 May;58(5):2598-607.
CAS Number
– 1038620-68-6
Molecular Weight
– 528.62
Compound Purity
– 99.71
SMILES
– O=C(C1=CC=C(NC2=C3N=CN(C4=CC=CC(F)=C4)C3=NC(N[C@H]5CC[C@H](N)CC5)=N2)C=C1)N6CCCCC6
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– DMSO : 12.5 mg/mL (ultrasonic)
Target
– Parasite
Isoform
– Plasmodium;Toxoplasma
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
