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PU02
SKU
HY-103118-10 mg
Category Reference compound
Tags 5-HT Receptor;Apoptosis, Apoptosis;GPCR/G Protein;Neuronal Signaling, Cancer; Neurological Disease
$70 – $670
Products Details
Product Description
– PU02, a derivative of 6-MP (HY-13677), is a negative allosteric modulator (NAM) of 5-HT3 receptor, with IC50 values of 0.36 and 0.73 μM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respectively[1][2].
Web ID
– HY-103118
Storage Temperature
– -20°C (Powder, stored under nitrogen)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C16H12N4S
References
– [1]Sarah M Trattnig, et al. Discovery of a novel allosteric modulator of 5-HT3 receptors: inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit site. J Biol Chem. 2012 Jul 20;287(30):25241-54.|[2]Xiao-Guang Yang, et al. 6-[(1-naphthylmethyl)sulfanyl]-9H-purine induces G2/M phase arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Eur J Pharmacol. 2012 Nov 15;695(1-3):27-33.
CAS Number
– 313984-77-9
Molecular Weight
– 292.36
Compound Purity
– 99.29
SMILES
– C12=NC=NC(SCC3=C4C=CC=CC4=CC=C3)=C1N=CN2
Clinical Information
– No Development Reported
Research Area
– Cancer; Neurological Disease
Solubility
– DMSO : 250 mg/mL (ultrasonic)
Target
– 5-HT Receptor;Apoptosis
Isoform
– 5-HT3 Receptor
Pathway
– Apoptosis;GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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