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PTPN22-IN-1
SKU
HY-139693-10 mg
Category Reference compound
Tags Cancer; Inflammation/Immunology, Metabolic Enzyme/Protease, Phosphatase
$400 – $3,400
Products Details
Product Description
– PTPN22-IN-1 is a potent PTPN22 inhibitor (IC50=1.4 µM; Ki=0.50 µM). PTPN22-IN-1 exhibits >7-10 fold selectivity for PTPN22 over similar phosphatases. PTPN22-IN-1 augments antitumor immune responses[1]. From WO2021007491A1 compound L-1.
Web ID
– HY-139693
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C26H21N3O5
References
– [1]Elizabeth Jaffee, et al. Targeting ptpn22 in cancer therapy. WO2021007491A1.
CAS Number
– 2580935-57-3
Molecular Weight
– 455.46
Compound Purity
– 99.89
SMILES
– O=C1C2=CC(NC([C@H](C)NC(C3=CC=C(C4=CC=CC=C4)C=C3)=O)=O)=CC=C2NC=C1C(O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology
Solubility
– DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Phosphatase
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.