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Products Details
Product Description
– PTG-0861 is a selective histone deacetylase 6 (HDAC6) inhibitor with the IC50 value of 5.92 nM. PTG-0861 induces apoptosis and can be used in the study of acute myeloid leukemia, multiple myeloma and other hematological cancers[1].
Web ID
– HY-150586
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C15H9F5N2O3
References
– [1]Justyna M Gawel，et al. PTG-0861: A novel HDAC6-selective inhibitor as a therapeutic strategy in acute myeloid leukaemia. Eur J Med Chem. 2020 Sep 1;201:112411.
CAS Number
– 2494082-34-5
Molecular Weight
– 360.24
SMILES
– O=C(NCC1=CC=C(C(NO)=O)C=C1)C2=C(F)C(F)=C(F)C(F)=C2F
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;HDAC
Isoform
– HDAC6
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
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