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Products Details
Product Description
– PTAC oxalate is a selective muscarinic receptor ligand. PTAC oxalate is an partial agonist of M2 and M4 but antagonist of M1, M3, and M5 (Ki values of 0.2-2.8 nM for hM1-5 in CHO cells). PTAC oxalate alleviates the mechanical allodynia on the neuropathic pain and has antidepression effects[1][2].
Web ID
– HY-107656
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C14H21N3O4S2
References
– [1]F P Bymaster, et al. Unexpected antipsychotic-like activity with the muscarinic receptor ligand (5R,6R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane. Eur J Pharmacol. 1998 Sep 4;356(2-3):109-19.|[2](5R,6R)6-(3-Propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1] Octane on a Mouse Model of Neuropathic Pain. Anesth Analg. 2017 Apr;124(4):1330-1338.
CAS Number
– 201939-40-4
Molecular Weight
– 359.46
SMILES
– CCCSC1=NSN=C1[C@@H]2[C@@H]3C[N@@](CCC3)C2.OC(C(O)=O)=O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– mAChR
Isoform
– mAChR1;mAChR2;mAChR3;mAChR4;mAChR5
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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