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Products Details
Product Description
– PSN 375963 hydrochloride is a potent GPR119 agonist, with EC50s of 8.4 and 7.9 μM for human and mouse GPR119, respectively. PSN 375963 hydrochloride shows similar potency to the endogenous agonist oleoylethanolamide (OEA)[1][2].
Web ID
– HY-108258A
Shipping
– Room temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C17H24ClN3O
References
– [1]Overton HA, et al. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. 2006;3(3):167-175.|[2]Ning Y, et al. Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on insulin secretion in MIN6c4 insulinoma cells. Br J Pharmacol. 2008;155(7):1056-1065.
CAS Number
– 1781834-82-9
Molecular Weight
– 321.84
SMILES
– CCCCC1CCC(C2=NC(C3=CC=NC=C3)=NO2)CC1.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Endocrinology
Solubility
– 10 mM in DMSO
Target
– GPR119
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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