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Products Details
Product Description
– PSEN1-IN-2 (Compound 13K) is a PSEN1 inhibitor. PSEN1-IN-2 inhibits PSEN1-APH1A and PSEN1-APH1B complex with IC50s of 6.9 and 2.4 nM. PSEN1-IN-2 can be used for Alzheimer’s disease research[1].
Web ID
– HY-156012
Shipping
– Room temperature
Molecular Formula
– C20H18ClFN2O3S
References
– [1]Narlawar R, et al. Discovery of brain permeable 2-Azabicyclo[2.2.2]octane sulfonamides as a novel class of presenilin-1 selective γ-secretase inhibitors. Eur J Med Chem. 2023 Nov 15;260:115725.
Molecular Weight
– 420.88
SMILES
– O[C@H]1C[C@@H]2CC[C@H]1[C@H](N2S(C3=CC=C(Cl)C=C3)(=O)=O)C4=CC=C(C#N)C=C4F
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– γ-secretase
Pathway
– Neuronal Signaling;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
