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Products Details
Product Description
– PSDalpha is an ERα degrader conjugating photosensitizer (PS), triphenylamine benzothiadiazole (TB) and 17β-estradiol via an acetylene bond. PSDalpha shows excellent anti-proliferation performance on MCF-7 cells. The maximum absorption wavelength of PSDalpha in the visible region is located at 465 nm[1].
Web ID
– HY-144314
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C44H39N3O2S
References
– [1]Silong Zhang, et al. Activable Targeted Protein Degradation Platform Based on Light-triggered Singlet Oxygen. J Med Chem. 2022 Feb 24;65(4):3632-3643.
Molecular Weight
– 673.86
SMILES
– O[C@@]1(CCC2[C@]1(CCC3C2CCC4=C3C=CC(O)=C4)C)C#CC5=CC=C(C6=CC=C(N(C7=CC=CC=C7)C8=CC=CC=C8)C=C6)C9=NSN=C59
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Estrogen Receptor/ERR
Isoform
– ERα
Pathway
– Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
