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PSB-0739
$130 – $1,200
Products Details
Product Description
– PSB-0739 is a high-affinity potent, competitive, nonselective platelet P2Y12 receptor antagonist with a Ki values of 24.9 nM. The P2Y12 receptor plays a crucial role in platelet aggregation. Antithrombotic effect[1].
Web ID
– HY-108660
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C26H17N3Na2O8S2
References
– [1]Younis Baqi, et al. High-affinity, non-nucleotide-derived competitive antagonists of platelet P2Y<sub>12</sub> receptors. J Med Chem. 2009 Jun 25;52(12):3784-93.|[2]Kristina Hoffmann, et al. Interaction of new, very potent non-nucleotide antagonists with Arg256 of the human platelet P2Y<sub>12</sub> receptor. J Pharmacol Exp Ther. 2009 Nov;331(2):648-55.|[3]J J Micklewright,et al. P2Y 12 receptor modulation of ADP-evoked intracellular Ca<sup>2+</sup> signalling in THP-1 human monocytic cells. Br J Pharmacol.2018 Jun;175(12):2483-2491.|[4]Gergely Horváth, et al. Central P2Y<sub>12</sub> receptor blockade alleviates inflammatory and neuropathic pain and cytokine production in rodents. Neurobiol Dis. 2014 Oct;70(100):162-78.
CAS Number
– 1052087-90-7
Molecular Weight
– 609.54
Compound Purity
– 98.67
SMILES
– O=S(C(C(N)=C1C2=O)=CC(NC3=CC=C(NC4=CC=CC=C4)C(S(=O)(O[Na])=O)=C3)=C1C(C5=C2C=CC=C5)=O)(O[Na])=O
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– H2O : 3.33 mg/mL (ultrasonic)
Target
– P2Y Receptor
Isoform
– P2Y12 Receptor
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
