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Product Description
– Protease-Activated Receptor-1 antagonist 3 is a potent protease-activated receptor-1 antagonist with an IC50 value of 7 nM. Protease-Activated Receptor-1 antagonist 3 shows binding affinity for hERG K+ channel with an IC50 value of 9 µM[1].
Web ID
– HY-143315
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C30H34N4O3
References
– [1]Mandal M, et al. Lead Optimization to Advance Protease-Activated Receptor-1 Antagonists in Early Discovery. J Med Chem. 2022 Apr 14;65(7):5575-5592.
Molecular Weight
– 498.62
SMILES
– [H][C@]12[C@H]([C@@H]([C@@H](C)[C@H]3[C@]1(C(O[C@@H]2C)=O)CN(C(NCC)=O)C3)C)/C=C/C4=CC=C(C=N4)C5=CC=CC=C5C#N
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Protease Activated Receptor (PAR)
Isoform
– PAR1
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
