Download Files:
Products Details
Product Description
– PROTAC TTK degrader-1 is a potent TTK (threonine tyrosine kinase) PROTAC degrader, with DC50 values of 1.7 and 5.8 nM in COLO-205 and HCT-116 cell, respectively. PROTAC TTK degrader-1 exhibits target degradation and anticancer efficacy in a xenograft mouse model of COLO-205 human colorectal cancer cells[1].
Web ID
– HY-143904
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C47H53N9O7
References
– [1]Lu J, Huang Y, Huang J, et al. Discovery of the First Examples of Threonine Tyrosine Kinase PROTAC Degraders. J Med Chem. 2022;65(3):2313-2328.
CAS Number
– 2953426-43-0
Molecular Weight
– 855.98
SMILES
– O=C1N(C2=NC(NC3=C(C=C(C=C3)N4CCN(CC4)C(CCCC#CC5=CC=C6C(N(CC6=C5)C7C(NC(CC7)=O)=O)=O)=O)OC)=NC=C2C(C)=C1)[C@@H]8CC[C@@H](CC8)NC(CC)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– PROTACs
Pathway
– PROTAC
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
