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Products Details
Product Description
– PROTAC TG2 degrader-1 (compound 11) is a von Hippel-Lindau (VHL)-based PROTAC targeting tissue transglutaminase (TG2) with a KD of 68.9 μM. PROTAC TG2 degrader-1 reduces TG2 in ovarian cancer cells in a proteasome-dependent manner[1].
Web ID
– HY-155643
Shipping
– Room temperature
Molecular Formula
– C55H73N9O10S
References
– [1]Andres Valdivia, et al. Discovery and Characterization of PROTACs Targeting Tissue Transglutaminase (TG2). J Med Chem. 2023 Jul 27;66(14):9445-9465.
Molecular Weight
– 1052.29
SMILES
– O=C([C@H]1N(C([C@H](C(C)(C)C)NC(CCOCCOCCOCCOCCOCCN(C2=NC(NC3=CC=C(NC(CC4=CC=CC=C4)=O)C=C3)=NC(C)=C2)C)=O)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Glutaminase;PROTACs
Isoform
– von Hippel-Lindau (VHL)
Pathway
– Metabolic Enzyme/Protease;PROTAC
Product type
– Reference compound
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