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Products Details
Product Description
– PROTAC Bcl-xL degrader-1 is a PROTAC that comprises a Bcl-xL (Bcl-2 family member) ligand binding group, a linker and an IAP E3 ligases binding group. PROTAC Bcl-xL degrader-1 is a potent Bcl-xL degrader, and shows toxicity for human platelets and MyLa 1929 cells with IC50 values of 62 nM and 8.5 μM, respectively[1].
Web ID
– HY-131188
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C76H96ClF3N10O11S3
References
– [1]Xuan Zhang, et al. Discovery of IAP-recruiting BCL-X L PROTACs as Potent Degraders Across Multiple Cancer Cell Lines. Eur J Med Chem. 2020 Aug 1;199:112397.
Molecular Weight
– 1514.28
SMILES
– ClC1=CC=C(C=C1)C2=C(CC(C)(CC2)C)CN3CCN(CC3)C4=CC=C(C=C4)C(NS(C5=CC=C(C(S(=O)(C(F)(F)F)=O)=C5)N[C@H](CCN6CCN(CC6)C(CCCOC7=CC8=C(C=C7)[C@H](NC([C@@H]9C(C)(C[C@@]([H])(N9C%10=O)OCC[C@@H]%10NC([C@@H](NC)C)=O)C)=O)CCC8)=O)CSC%11=CC=CC=C%11)(=O)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Bcl-2 Family;PROTACs
Isoform
– Bcl-xL;cIAP1
Pathway
– Apoptosis;PROTAC
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
