Download Files:
PROTAC AR-V7 degrader-1
$590 – $4,800
Products Details
Product Description
– PROTAC AR-V7 degrader-1 (Compound 6) is a potent, orally bioavailable and selective AR-V7 degrader with the DC50 of 0.32 µM by recruiting VHL E3 ligase to Androgen receptor (AR) DNA binding domain (DBD) binder. PROTAC AR-V7 degrader-1 exhibits activity against 22Rv1 cell-line expressing AR-V7 with the EC50 of 0.88 µM[1].
Web ID
– HY-145479
Storage Temperature
– -20°C (Powder, protect from light)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C41H52N6O6S2
References
– [1]Archana Bhumireddy, et al. Design, synthesis, and biological evaluation of phenyl thiazole-based AR-V7 degraders. Bioorg Med Chem Lett. 2022 Jan 1;55:128448.
CAS Number
– 2767440-24-2
Molecular Weight
– 789.02
Compound Purity
– 99.34
SMILES
– O=C(CCCCOC1=CC=C(C2=CSC(N3CCOCC3)=N2)C=C1)N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@H](C4)O)C(N[C@H](C5=CC=C(C=C5)C6=C(N=CS6)C)C)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 110 mg/mL (ultrasonic)
Target
– Androgen Receptor;PROTACs
Isoform
– von Hippel-Lindau (VHL)
Pathway
– PROTAC;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
