Products Details

Product Description

– Prostaglandin E1-d4 is the deuterium labeled Prostaglandin E1. Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases[1][2][3].

Web ID

– HY-B0131S

Shipping

– Room temperature

Applications

– Metabolism-protein/nucleotide metabolism

Molecular Formula

– C20H30D4O5

References

– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Kiriyama M, et, al. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24.|[3]Cattaneo MG, et, al. Alprostadil suppresses angiogenesis in vitro and in vivo in the murine Matrigel plug assay. Br J Pharmacol. 2003 Jan;138(2):377-85.|[4]Hauck EW, et, al. Prostaglandin E1 long-term self-injection programme for treatment of erectile dysfunction–a follow-up of at least 5 years. Andrologia. 1999;31 Suppl 1:99-103.

CAS Number

– 211105-33-8

Molecular Weight

– 358.51

SMILES

– C(CCC(C(CC(O)=O)([2H])[2H])([2H])[2H])[C@@H]1[C@@H](/C=C/[C@H](CCCCC)O)[C@H](O)CC1=O

Clinical Information

– No Development Reported

Research Area

– Endocrinology; Cardiovascular Disease

Solubility

– 10 mM in DMSO

Target

– Endogenous Metabolite;Isotope-Labeled Compounds;Prostaglandin Receptor

Isoform

– EP

Pathway

– GPCR/G Protein;Metabolic Enzyme/Protease;Others

Product type

– Isotope-Labeled Compounds

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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