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Propranolol
$150 – $165
Products Details
Product Description
– Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3].
Web ID
– HY-B0573B
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C16H21NO2
Citations
– Am J Pathol. 2023 Apr 21;S0002-9440(23)00132-3.|Environ Toxicol. 2023 Dec 2.|Exp Neurol. 2023 Apr 19;114418.|iScience. 2023 Jul 19.|J Chromatogr B. 2023 Jun 20, 123804.|J Pharmaceut Biomed. 2020, 113870.|Nat Commun. 2023 May 2;14(1):2523.|Pharmacol Res Perspect. 2020 Apr;8(2):e00575.|Pharmacol Res Perspect. 2021 Oct;9(5):e00879.|Research Square Print. December 21st, 2022.|Sci Signal. 2020 Nov 24;13(659):eaax0273.|Behav Brain Res. 28 October 2021, 113642.|Biochem Biophys Res Commun. 2023 Mar 21;657:69-79.|BMC Pulm Med. 2021 Jun 5;21(1):189.|Chemosphere. 2019 Jun;225:378-387. |J Endocrinol. 2020 Mar;244(3):459-471.|Psychopharmacology. 2023 Jun 17.
References
– [1]Briley M, et al. Evidence against beta-adrenoceptor blocking activity of diltiazem, a drug with calcium antagonist properties. Br J Pharmacol. 1980 Aug;69(4):669-73.|[2]Al-Majed AA, et al. Propranolol. Profiles Drug Subst Excip Relat Methodol. 2017;42:287-338.|[3]Munabi NC, et al. Propranolol Targets Hemangioma Stem Cells via cAMP and Mitogen-Activated Protein Kinase Regulation. Stem Cells Transl Med. 2016 Jan;5(1):45-55.|[4]Galandrin S, et al. Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy. Mol Pharmacol. 2006 Nov;70(5):1575-84. Epub 2006 Aug 1
CAS Number
– 525-66-6
Molecular Weight
– 259.34
Compound Purity
– 99.87
SMILES
– OC(COC1=C2C=CC=CC2=CC=C1)CNC(C)C
Clinical Information
– Launched
Research Area
– Neurological Disease; Cardiovascular Disease; Endocrinology; Cancer
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– Adrenergic Receptor;Bacterial
Isoform
– β adrenergic receptor
Pathway
– Anti-infection;GPCR/G Protein;Neuronal Signaling
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
