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Products Details
Product Description
– PRMT4-IN-1 is a selective inhibitor of PRMT4 (IC50=3.2 nM). PRMT4-IN-1 inhibits MCF7 relative viability[1].
Web ID
– HY-146810
Shipping
– Room temperature
Molecular Formula
– C30H36N10O7
References
– [1]Iannelli G, et al. Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach. J Med Chem. 2022 Sep 8;65(17):11574-11606.
Molecular Weight
– 648.67
SMILES
– O=C(OC)C1=CC(O)=C2C=C(NC(NCCCCNC(NC/C=C/[C@H]3O[C@@H](N4C=NC5=C(N)N=CN=C45)[C@H](O)[C@@H]3O)=N)=O)C=CC2=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Histone Methyltransferase
Isoform
– PRMT1;PRMT3;PRMT4;PRMT5;PRMT6;PRMT7;PRMT8
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
