Download Files:
Pregnenolone 16α-carbonitrile
$50 – $130
Products Details
Product Description
– Pregnenolone 16α-carbonitrile is an orally active prototypical and effective rodent-PXR activator. Pregnenolone 16α-carbonitrile, a synthetic steroid, induces cytochrome P450 3A expression. Pregnenolone 16α-carbonitrile exhibits increased resistance to subsequent stressful insults[1][2][3].
Web ID
– HY-131723
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C22H31NO2
References
– [1]Yang Xie, et al. Activation of Pregnane X Receptor Sensitizes Mice to Hemorrhagic Shock-Induced Liver Injury. Hepatology. 2019 Sep;70(3):995-1010.|[2]Simon Lowes, et al. The Effects of Pregnenolone 16α-Carbonitrile Dosing on Digoxin Pharmacokinetics and Intestinal Absorption in the Rat. Pharmaceutics. 2010 Mar 15;2(1):61-77.|[3]Jeffrey Guzelian, et al. Identification of genes controlled by the pregnane X receptor by microarray analysis of mRNAs from pregnenolone 16alpha-carbonitrile-treated rats. Toxicol Sci. 2006 Dec;94(2):379-87.|[4]Carylyn J Marek, et al. Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms. Biochem J. 2005 May 1;387(Pt 3):601-8.
CAS Number
– 1434-54-4
Molecular Weight
– 341.49
Compound Purity
– 98.48
SMILES
– C[C@@]12[C@](C[C@H]([C@@H]2C(C)=O)C#N)([H])[C@@]3([H])[C@]([C@@]4(C(C[C@H](CC4)O)=CC3)C)([H])CC1
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– DMSO : 20 mg/mL (ultrasonic)
Target
– Cytochrome P450
Isoform
– CYP2;CYP3
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
