Download Files:
PQR620
$120 – $1,800
Products Details
Product Description
– PQR620 is an orally bioavailable and selective brain penetrant inhibitor of mTORC1/2[1].
Web ID
– HY-100026
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C21H25F2N7O2
References
– [1]Florent Beaufils, et al. Abstract 1336: Structure-activity relationship studies, synthesis, and biological evaluation of PQR620, a highly potent and selective mTORC1/2 inhibitor. Cancer Research; 2016 Apr 16-20.|[2]Chiara Tarantelli, et al. Targeting the PI3K/mTOR Pathway in Lymphoma with PQR309 and PQR620: Single Agent Activity and Synergism with the BCL2 Inhibitor Venetoclax. Blood 2016 128:3017.
CAS Number
– 1927857-56-4
Molecular Weight
– 445.47
Compound Purity
– 98.33
SMILES
– [H][C@]1(CC[C@]([H])2COC1)N2C3=NC(N4[C@]5([H])CC[C@]([H])4COC5)=NC(C6=CN=C(N)C=C6C(F)F)=N3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 6.4 mg/mL (warming)
Target
– mTOR
Isoform
– mTORC1;mTORC2
Pathway
– PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
