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PPNDS (tetrasodium)
$110 – $330
Products Details
Product Description
– PPNDS tetrasodium is a selective and competitive meprin β inhibitor (IC50: 80 nM, Ki: 8 nM), and also inhibits ADAM10 (IC50: 1.2 μM). PPNDS tetrasodium is also a P2X1 receptor antagonist. PPNDS is an agonist for the ATP receptor of Paramecium. PPNDS tetrasodium potently inhibits polymerases from viruses. PPNDS tetrasodium can be used in the research of infection and cancers[1][3][4].
Web ID
– HY-108675
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– COVID-19-anti-virus
Molecular Formula
– C18H11N4Na4O14PS2
References
– [1]Franck Madoux, et al. Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β. Biopolymers. 2014 Sep;102(5):396-406. |[2]Romina Croci, et al. PPNDS inhibits murine Norovirus RNA-dependent RNA-polymerase mimicking two RNA stacking bases. FEBS Lett. 2014 May 2;588(9):1720-5. |[3]Christopher R Wood, et al. PPNDS is an agonist, not an antagonist, for the ATP receptor of Paramecium. J Exp Biol. 2003 Feb;206(Pt 3):627-36. |[4]Natalie E Netzler, et al. Broad-spectrum non-nucleoside inhibitors for caliciviruses. Antiviral Res. 2017 Oct;146:65-75.
CAS Number
– 1021868-77-8
Molecular Weight
– 694.36
Compound Purity
– 96.39
SMILES
– O=CC1=C(C(C)=NC(/N=N/C2=CC(S(=O)(O[Na])=O)=C(C=C([N+]([O-])=O)C=C3S(=O)(O[Na])=O)C3=C2)=C1COP(O[Na])(O[Na])=O)O
Clinical Information
– No Development Reported
Research Area
– Cancer; Infection
Solubility
– H2O : 37.5 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– MMP;P2X Receptor
Isoform
– ADAM10;P2X1 Receptor
Pathway
– Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
