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PPM-18
SKU
HY-118160-Get quote
Category Reference compound
Tags Immunology/Inflammation, Inflammation/Immunology; Cancer, NO Synthase
Products Details
Product Description
– PPM-18 (NSC 73233), a potent anti-inflammatory agent, inhibits nitric oxide synthase expression. PPM-18 is a potent inhibitor of iNOS expression by blocking the binding of NF-κB to promoter[1]. PPM-18, an analog of Vitamin K, induces autophagy and apoptosis in bladder cancer cells through ROS and AMPK signaling pathways[2].
Web ID
– HY-118160
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C17H11NO3
References
– [1]S M Yu, et al. Inhibition of nitric oxide synthase expression by PPM-18, a novel anti-inflammatory agent, in vitro and in vivo. Biochem J. 1997 Dec 1;328 ( Pt 2)(Pt 2):363-9.|[2]Huiai Lu, et al. PPM-18, an Analog of Vitamin K, Induces Autophagy and Apoptosis in Bladder Cancer Cells Through ROS and AMPK Signaling Pathways. Front Pharmacol. 2021 Jul 9;12:684915.
CAS Number
– 65240-86-0
Molecular Weight
– 277.27
SMILES
– O=C(NC(C1=O)=CC(C2=C1C=CC=C2)=O)C3=CC=CC=C3
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology; Cancer
Solubility
– 10 mM in DMSO
Target
– NO Synthase
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.