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Products Details
Product Description
– Ppc-1 is a mitochondrial uncoupler. Ppc-1 enhances mitochondrial oxygen consumption without adverse effects on ATP production. Ppc-1 is a cell-permeate interleukin-2 (IL-2) inhibitor. Ppc-1 inhibits the Gram-negative periodontopathogen Porphyromonas gingivalis. Ppc-1 has anti-obesity, antibacterial and anti-inflammatory activities[1][2][3][4].
Web ID
– HY-117843
Shipping
– Room temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C21H25NO4
References
– [1]Haruhisa Kikuchi a, et al. Novel prenylated and geranylated aromatic compounds isolated from Polysphondylium cellular slime molds. Tetrahedron 66 (2010) 6000-6007.|[2]Azelmat J, et al. Antibacterial and Anti-inflammatory Activities of Ppc-1, Active Principle of the Cellular Slime Mold Polysphondylium pseudo-candidum. Med Chem. 2015;11(7):666-9.|[3]Suzuki T, et al. Weight loss by Ppc-1, a novel small molecule mitochondrial uncoupler derived from slime mold. PLoS One. 2015 Feb 10;10(2):e0117088.|[4]Ogura M, et al. Prenylated quinolinecarboxylic acid derivative suppresses immune response through inhibition of PAK2. Biochem Pharmacol. 2016 Apr 1;105:55-65.
CAS Number
– 1245818-17-0
Molecular Weight
– 355.43
SMILES
– O=C(C1=NC2=C(OC/C=C(C)/C)C=CC=C2C(OC)=C1)OC/C=C(C)C
Clinical Information
– No Development Reported
Research Area
– Infection; Metabolic Disease; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Bacterial;Interleukin Related;Mitochondrial Metabolism
Isoform
– IL-2
Pathway
– Anti-infection;Immunology/Inflammation;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
