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Products Details
Product Description
– PPARα/δ agonist 1 is a potent PPARα/PPARδ dual agonist (PPARα EC50=7.0 nM; PPARδ EC50=8.4 nM). PPARα/δ agonist 1 is a high selectivity over PPARγ (PPARγ EC50=1316.1 nM). PPARα/δ agonist 1 has the potential for the research of nonalcoholic steatohepatitis[1].
Web ID
– HY-144111
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C22H22F3N3O5
References
– [1]Feng Z, et al. Design, Synthesis, and Biological Evaluation of Triazolone Derivatives as Potent PPARα/δ Dual Agonists for the Treatment of Nonalcoholic Steatohepatitis. J Med Chem. 2022;65(3):2571-2592.
CAS Number
– 2760128-48-9
Molecular Weight
– 465.42
SMILES
– O=C1N(N=CN1C2=CC=C(C=C2)OC(F)(F)F)CC3=CC(C)=C(C(C)=C3)OC(C)(C(O)=O)C
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– PPAR
Isoform
– PPARα;PPARγ;PPARδ
Pathway
– Cell Cycle/DNA Damage;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
