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Products Details
Product Description
– PPARδ agonist 9 (compound 21) is a PPARδ agonist (EC50: 3.6 nM). PPARδ agonist 9 has in vivo efficacy, reducing serum levels of MCP-1 in mice and significantly inhibiting atherosclerosis progression in the LDLr-KO model (inhibition rate: 50-60%)[1].
Web ID
– HY-149429
Shipping
– Room temperature
Molecular Formula
– C26H28ClF3N4O3S
References
– [1]Kato T, et al. Design, Synthesis, and Anti-Inflammatory Evaluation of a Novel PPARδ Agonist with a 4-(1-Pyrrolidinyl)piperidine Structure. J Med Chem. 2023 Aug 24;66(16):11428-11446..
CAS Number
– 928023-21-6
Molecular Weight
– 569.04
SMILES
– ClC1=CC(CC(O)=O)=CC(OCCC2(N3CCCC3)CCN(C4=NC5=CC=C(N=C5S4)C(F)(F)F)CC2)=C1
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– PPAR
Pathway
– Cell Cycle/DNA Damage;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
