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Products Details
Product Description
– p,p’-DDE-d8 is the deuterium labeled p,p’-DDE[1]. p,p’-DDE (4,4′-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM[2].
Web ID
– HY-B1986S
Shipping
– Room temperature
Molecular Formula
– C14D8Cl4
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Kelce WR, et al. Persistent DDT metabolite p,p’-DDE is a potent androgen receptor antagonist. Nature. 1995;375(6532):581-585.
CAS Number
– 93952-19-3
Molecular Weight
– 326.07
SMILES
– Cl/C(Cl)=C(C1=C([2H])C([2H])=C(C([2H])=C1[2H])Cl)/C2=C([2H])C([2H])=C(C([2H])=C2[2H])Cl
Clinical Information
– No Development Reported
Research Area
– Endocrinology
Solubility
– 10 mM in DMSO
Target
– Androgen Receptor;Drug Metabolite
Pathway
– Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
