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Products Details
Product Description
– Pomstafib-2 is a potent and selective STAT5b inhibitor. Pomstafib-2 decreases the expression of pSTAT5b and induces Apoptosis[1][2].
Web ID
– HY-112649
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C52H66N2O20P2
References
– [1]Elumalai N, et al. Rational development of Stafib-2: a selective, nanomolar inhibitor of the transcription factor STAT5b. Sci Rep. 2017 Apr 11;7(1):819.|[2]Gräb J, et al. The STAT5b Linker Domain Mediates the Selectivity of Catechol Bisphosphates for STAT5b over STAT5a. ACS Chem Biol. 2019 Apr 19;14(4):796-805.
CAS Number
– 2332841-83-3
Molecular Weight
– 1101.03
SMILES
– O=C(NCC1=CC=C(OP(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)C(OP(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)=C1)COC2=CC=C(C(NC3=CC=C(OC4=CC=CC=C4)C=C3)=O)C=C2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;STAT
Pathway
– Apoptosis;JAK/STAT Signaling;Stem Cell/Wnt
Product type
– Reference compound
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