Download Files:
POMHEX
$450 – $2,550
Products Details
Product Description
– POMHEX, a racemic mixture and a cell-permeable pivaloyloxymethyl (POM) proagent of HEX, is a potent, ENO2-specific inhibitor of enolase. POMHEX exhibits low-nanomolar potency against ENO1-deleted cells in vitro and is capable of eradicating ENO1-deleted xenografted tumours in vivo. POMHEX is a potent glycolysis inhibitor[1].
Web ID
– HY-131904
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C17H30NO9P
References
– [1]Yu-Hsi Lin, et al. An enolase inhibitor for the targeted treatment of ENO1-deleted cancers. Nat Metab. 2020 Nov 23.
CAS Number
– 2004714-34-3
Molecular Weight
– 423.40
Compound Purity
– 99.77
SMILES
– O=P(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)C1C(N(O)CCC1)=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Metabolic Disease
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– Apoptosis;Enolase
Pathway
– Apoptosis;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
