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Products Details
Product Description
– Pomalidomide-amido-C3-piperazine-N-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183)[1].
Web ID
– HY-131186
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C27H33N5O8
References
– [1]Binbin Cheng, et al. Discovery of Novel Resorcinol Diphenyl Ether-Based PROTAC-like Molecules as Dual Inhibitors and Degraders of PD-L1. Eur J Med Chem. 2020 Aug 1;199:112377.
Molecular Weight
– 555.58
SMILES
– O=C(CCCC(N1CCN(CC1)C(OC(C)(C)C)=O)=O)NC2=CC=CC(C(N3C(C(N4)=O)CCC4=O)=O)=C2C3=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– E3 Ligase Ligand-Linker Conjugates
Isoform
– Cereblon
Pathway
– PROTAC
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
